Can you trust the results from gut microbiome tests? Maybe not

Can you trust the results from gut microbiome tests? 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Maybe not Read this before you make health decisions based on a consumer test of your gut microbes The National Institute of Standards and Technology created a standardized fecal sample. Companies that analyzed identical samples of the standard produced results as varied as the microbes carried by different people. NIST By Tina Hesman Saey 5 hours ago Share this:Share Share via email (Opens in new window) Email Share on Facebook (Opens in new window) Facebook Share on Reddit (Opens in new window) Reddit Share on X (Opens in new window) X Print (Opens in new window) Print Listen to this article This is a human-written story voiced by AI. Got feedback? Take our survey . (See our AI policy here .) Finding out what gut microbes a person carries may not be as easy as many companies advertise. Seven direct-to-consumer microbiome testing companies each got three identical fecal samples but returned different results about which gut microbes were present, researchers report February 26 in Communications Biology. The results highlight discrepancies among companies that claim to give consumers insight about their gut health. That matters because consumers may take probiotics they don’t need, change their diets in harmful ways or even get fecal transplants based on inaccurate microbiome test results, say researchers from the University of Maryland in Baltimore and the National Institute of Standards and Technology in Gaithersburg, Md. (Molecular geneticist Scott Jackson has since left NIST and is now a consultant for companies whose products involve microbes.) Sign up for our newsletter We summarize the week's scientific breakthroughs every Thursday. The NIST team created a fecal standard by putting bowel movements from multiple people in a blender to create a homogenized sample. “We know that it is identical in biology across all those samples,” NIST microbiologist Stephanie Servetas said February 25 during a news briefing. “What this material is meant to do is really to say how reproducible are the results, either between companies or within a company, but it’s not going to be able to tell us who was closest to the correct answer.” Some companies were consistent with the microbes they identified across the three samples. But one company produced a drastically different result on one of the three samples it tested. It classified the two similar results as “healthy” and the outlier as “unhealthy.” Others identified many of the same types of bacteria across the replicated samples but showed varying amounts of those bacteria. The discrepancies between the companies’ results on the standard sample were similar to variability among samples that came from different people. NIST began selling the fecal standard to companies last year to use for calibration and quality control, which may result in improved testing methods in the future, Servetas said. The aim isn’t to force companies to adopt the same methods or to stifle innovation, she said, but “there should be some minimum guidelines and some controls” that would make results more consistent.  One sample, three results One company had big inconsistencies in the genera of microbes (indicated by different colors with gray being unspecified) it identified in three replicates of a standard sample. The company classified the first two results as healthy and the third as unhealthy. S.L. Servetas et al./Communications Biology 2026S.L. Servetas et al./Communications Biology 2026 Questions or comments on this article? E-mail us at feedback@sciencenews.org | Reprints FAQ Citations S.L. Servetas et al. Evaluating